Toonstruck
Toonstruck is an adventure game released in 1996 in which, although all the images were drawn and scanned into the game, the protagonist Drew Blanc (played and voiced by Christopher Lloyd) is an actual, videotaped representation of the actor (the name is a pun, as the character "went blank" when he came up with a new idea for a character). Drew's sidekick, roughly called Flux Wildly, is a drawn character voiced by Dan Castellaneta. Toonstruck also includes scan-line compressed FMV and was one of the first video games to include music by APM Music, most notably the classic "Spooky Scherzo" by Sam Fonteyn and "Lonely Hearts Club A" by David Bell.